Pharmachologic effect
Semisynthetic antibiotic of the tetracycline group of the broad spectrum of action. Has a bacteriostatic effect.
Active against gram-positive microorganisms:
Aerobic cocci – Staphylococcus spp. (Including those producing penicillinase), Streptococcus spp., Including Streptococcus pneumoniae.
Aerobic spore-forming bacteria – Bacillus anthracis; Aerobic non-spore-forming bacteria – Listeria monocytogenes; Anaerobic spore-forming bacteria – Clostridium spp.
The drug is also active against gram-negative microorganisms:
Aerobic cocci – Neisseria gonorrhoeae.
Aerobic bacteria – Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis.
The drug is also active against Rickettsia spp., Treponema spp., Mycoplasma spp. And Chlamydia spp.
The drug is resistant to Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides fragilis.
Indications for use
Infectious diseases caused by susceptible to doxycycline pathogens.
To prevent the development of resistance and maintain effectiveness, the drug should be used only to treat infections caused by proven (or presumably) susceptible to doxycycline microorganisms. In the presence of information on the identified pathogen and its sensitivity to antibiotics, the physician is guided by it to select the optimal antibiotic, and in the absence of such an empirical choice of an antibacterial agent is performed on the basis of local epidemiological data and sensitivity data.
Doxycycline is indicated for the treatment of the following infections:
• Spotted fever in the rocky mountains, typhus and other typhus, Ku-fever, vesicular rickettsiosis and tick-borne fevers caused by rickettsia;
• respiratory infections caused by Mycoplasmapneumoniae;
• venereal lymphogranulomatosis caused by Chlamydiatrachomatis;
• psittacosis caused by Chlamydiapsittaci;
• trachoma caused by Chlamydiatrachomatis, although it is not always possible to achieve excision of the pathogen, as evidenced by the results of immunofluorescence studies;
• conjunctivitis with inclusions caused by Chlamydiatrachomatis, doxycycline can be. Use orally in the form of monotherapy or in combination with topical preparations;
• undeveloped urethral, endocervical and rectal infections caused by Chlamydiatrachomatis in adults;
Contraindications
Contraindications for the appointment of Doxycycline are: increased sensitivity to Doxycycline or other tetracyclines; Severe hepatic impairment; Systemic lupus erythematosus; Decreased number of leukocytes in the blood; An increased amount of porphyrins in the blood (a special pigment that is part of the hemoglobin); Lactose intolerance; Glucose-galactose malabsorption (a violation of absorption of galactose and glucose, inherited); Deficiency of lactase (congenital pathology); Pregnancy (may be prescribed only for life indications); Children’s age till 8 years; Children age over 12 years with a body weight of less than 45 kg.